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Further, superiority of semaglutide 14 mg compared to placebo was not demonstrated based on the primary outcome in the trial

Rather, physicians should support and encourage patients to make sustainable improvements in their diet quality and physical activities if these behaviors fail to meet national guidelines

professional guidance for weight management in general sometimes uses gentle early milestones (for example, a few percent of body weight over the first month) to gauge trajectorynot as a guarantee, but as a conversation starter

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In some cases, adding folate improves neurologic symptoms when B12 alone does not