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CAFs display a range of tumour-supporting functions, including migration, metastasis, angiogenesis, resistance to chemotherapy and immunosuppression ( The prototype of fibroblast-mediated diseases is undoubtedly fibrosis

GLP-1 receptor agoniststhe class of drugs that includes semaglutide (Ozempic, Wegovy), liraglutide (Victoza, Saxenda), and tirzepatide (Mounjaro, Zepbound)are synthetic molecules engineered to mimic and amplify this exact hormonal signal

(0.03 MB DOC) Figure S1

The generation, detection, and effects of reactive drug metabolites

Notably, an analysis of hepatic gene expression of MAFLD patients showed that the expression of FMO1 but not FMO3 increases in MAFLD ( Statements Author contributions XL and JH participated in drafting the manuscript