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Apr 20 2021 Hashemi et al., Journal of Biomolecular Structure and Dynamics, doi:10.1080/07391102.2021.1910570 The in silico mechanism of hVKOR interaction with acetaminophen and its metabolite, as well as N-acetyl cysteine: caution on application in COVID-19 patients In silico study suggesting increased risk of cerebral hemorrhage with acetaminophen use for COVID-19

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Non-anatomical factors, such as neuromuscular control of the airway and systemic inflammation, also play a significant role in the condition