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The titration schedule in the clinical trial was a minimum timeline, not a mandate

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5 Persistence and discontinuation Persistence with GLP-1 therapy has been a major concern

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Historically, GLP-1-class compounds produce somewhat lower percent weight loss in diabetic populations than in non-diabetic ones

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Retatrutide is useful in this context as a consistent perturbation tool that can be applied under controlled exposure logic across assay layers

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