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Additionally, these liposomes act as permeation enhancers by interacting with and disrupting the organized lipid matrix of the SC, particularly by altering the structure of the intracellular lipid lamellae

Thus, although the increase in CNS-GLP-1R signaling is sufficient to activate BAT thermogenesis, whether this regulation is necessary for the contribution of BAT thermogenesis to the control of energy balance, or to the body weight lowering effects of GLP-1 based therapies still requires further investigation

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