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doi:10.7759/cureus.70279 Yarizadh H, Shab-Bidar S, Zamani B, Vanani AN, Baharlooi H, Djafarian K
Mojca Jensterle, from the University Medical Center Ljubljana, explains: "The combined action of both pharmacotherapies, GLP-1 and metformin, may be more effective than the individual action of each drug for the treatment of the metabolic and reproductive disturbances linked to PCOS and may even improve metabolic outcomes in women who previously exhibited deficient responses to metformin." Mojca Jensterle, Department of Endocrinology, University Medical Center Ljubljana Interestingly, metformin has the ability to enhance the bodys natural GLP-1 levels, which might allow for lower doses of GLP-1 receptor agonists without sacrificing results
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This may be plausible given the interspersed heterologous contact between alfa- and beta-cells in the pancreas of primates (89, 90), and the possibility that beta-cells may have cytoplasmic extensions that span alfa-cells (89)
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