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Despite the availability of cryo-EM structures of bovine MRP1 in complex with and without the ligand LTC4 ( Evaluation of the AlphaFold predicted model protein structures was performed using pLDDT (predicted Local Distance Difference Test) (Jumper et al., 2021), ProSA (Sippl, 1993), ERRAT (Laskowski et al., 1993), and assessment tools (clashscore and MolProbity (Williams et al., 2018)) integrated within the SWISS-MODEL workspace (Waterhouse et al., 2018)

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Clinically significant weight loss was achieved in 46% of all participants, with rare individuals experiencing a decrease of 15%

Sustained Results: When used regularly as part of a care plan, TPIs can help manage chronic pain over time