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Christensen MB, Lund AB, Jrgensen NR, Holst JJ, Vilsbll T, Knop FK (2020) Glucose-dependent insulinotropic polypeptide (GIP) reduces bone resorption in patients with type 2 diabetes

Methods Transbilayer solute diffusion simulations Unbiased atomic detail MD simulations were performed using GROningen MAchine for Chemical Simulations (GROMACS) (www.gromacs.org) 17 , in combination with the Chemistry at HARvard Macromolecular Mechanics (CHARMM) 18 general force field (CGenFF) 19 for molecular solutes and the transferable intermolecular potential with 3 points (TIP3P) water model as solvent 20 , Lipids parameters were taken from the CHARMM36 all-atom force field 21

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3.2 Clostridium in RA RA is a kind of AD that affects the whole body and predominantly the joints (113), which is the result of immune dysregulation, such as aberrant immune activation and impaired immune tolerance (114)