The use of TRESIBA for this indication is supported by evidence from an adequate and well-controlled trial and a pharmacokinetic study (trials included pediatric patients 1 year of age and older with type 1 diabetes mellitus) [see Clinical Pharmacology (12.3) and Clinical Studies (14.2)]
[DOI] [PMC free article] [PubMed] 292.Castilla-Cortzar I, Aliaga-Montilla MA, Salvador J, Garca M, Delgado G, Gonzlez-Barn S, Quiroga J, Prieto J
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The level of GSH/GSSG in the cells treated with NS for more than 6 h was also significantly decreased, but the extent was smaller than that in the NSBSO group, indicating that the combination of consumption of existing GSH and inhibition of GSH synthesis promotes the exhaustion of GSH in cells
Further studies are essential to solve these problems, which may lead to new strategies for obesity treatment