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Here, we review several issues that may be considered controversial in the field, considering each line of evidence independently and in the light of all other lines of evidence

But serious health problems can arise for some individuals taking vitamin B12 at higher dosages

The total vagotomy can be beneficial in reducing the chances of developing secondary PD, according to a cohort study done in Denmark (Svensson et al., 2015)

The resulting systemic inflammation can cross the BBB, initiating neuroinflammation in the brain

Glutathione is involved in amino acid transport across cell membranes via a process known as the glutathione cycle (historically but incorrectly referred to as the -glutamyl cycle)