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4a, compared with OA group, the body weight of rats in OA + saline had no significant change at 0 day ( P = 0.9993), 7th day ( P = 0.8538), 14th day ( P = 0.5209), 21st day ( P = 0.3575) and 28th day ( P = 0.8092) after treatment with saline, which indicated that saline could not induce weight loss

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One of the latest advancements is the use of GLP-1 receptor agonists (GLP-1 RAs) have gained popularity in the past few years for weight loss in obese and overweight individuals

They are injected under the skin and can generally be taken at any time of day, with or without food

Similarly, dedicated macrophages of the CNS and microglia-like cells are present in annelids and in vertebrates (Figure 2)