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Structural diversity among agonist-bound states has been directly visualized by cryo-EM of GLP-1R in complex with multiple peptide agonists, confirming that conformational plasticity at the extracellular face propagates to the G protein interface in agonist-specific ways (Cary et al., 2021)

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[DOI] [PubMed] [Google Scholar] 39.Lubitz I., Ricny J., Atrakchi-Baranes D., Shemesh C., Kravitz E., Liraz-Zaltsman S., Maksin-Matveev A., Cooper I., Leibowitz A., Uribarri J., et al

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