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However, considerable amounts of ROS at the molecular level can cause cellular and tissue damage, damaging nucleic acids, proteins, organelles, and membranes and inducing cell death or apoptosis (40, 41)

Gough SC, Bode B, Woo V, et al

Rapid weight loss (more than 2 to 3 pounds per week sustained over months) gives the skin less time to adapt and begin its natural remodeling process

( 7 ) Chronic stress can also contribute to hormone imbalances

In controls a basal expression of GFAP is indeed observed, but this is topographically limited to the inner retinal layer (Figure 1a, 1) both in controls and in animals not subjected to the hypertensive shock but simply treated with carnitine (not shown)