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Physiol Rev 83:731801 Attaix D, Combaret L, Kee AJ (2003) Thaillandier D (2003) Mechanisms of ubiquitination and proteasome-dependent proteolysis in skeletal muscle

Mechanistically, Epitalons effect appears to involve a direct interaction with promoter regions of the telomerase gene, where it binds specific DNA sequences (such as ATTTC motifs), potentially modulating transcriptional activity