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Oxidative stress responses clarified the functioning of central principal switches like nuclear factor (NF)-B (NFB) or the Kelch-like ECH-associated protein 1 (Keap1)-Nuclear factor erythroid 2-related factor2 (Nrf2)-antioxidant response element (ARE) redox regulator pathway (Sies, 2015

The reducing E GSH [IMS] further opens up the possibility of redox regulation by reversible disulphide bond formation upon slight deflections of E GSH (Riemer et al , 2009

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