By early 2025, FDA had issued draft guidance on AI model credibility (for drug submissions) ( [5] ) and even collaborated with the European Medicines Agency to publish Guiding Principles of Good AI Practice in Drug Development (January 2026) ( [21] )
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We also monitored ligand-induced G s conformational changes (associated with G s activation and cAMP signalling) and receptor trafficking into FYVE-containing early endosomes, where continued peptide-mediated signalling can contribute to cellular response ( Figures 1 & S1 )
Despite the significant therapeutic potential of these metabolites, further investigations are needed for evidence-based clinical applications
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