made use of the RPTEC/TERT1 cell line to evaluate transepithelial transports in a small set of known nephrotoxic and non-nephrotoxic drugs, demonstrating that further evaluation of functional parameters, including transepithelial electrical resistance (TEER), reabsorption, and secretion of solutes, is essential to understand the nephrotoxicity mechanisms of drugs and predict the in vivo implication in regards to kidney performance (Secker et al
These outcomes represent a substantial advancement over existing pharmacological options for obesity, with 89-96% of participants achieving at least 5% weight loss and 55-63% achieving 20% or greater weight reduction
We found that ferroptosis of ESCs induced VEGFA and IL8 secretion, and explored its potential effects on angiogenesis of adjacent lesions during the development of endometriosis
PubMed Central , Primary Carnitine Deficiency: MedlinePlus Genetics
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