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Recent emerging studies, such as the investigation into Aconitum pendulum polysaccharides (APPs), have explicitly recognized this limitation, stating that while microbial shifts were observed, causal verification via FMT remains essential for future validation ( in vivo blocking), thus forming the shortest closed-loop evidence chain of key molecules-key receptors/pathways-key phenotypes

Further research on these mechanisms has the potential to lead to more personalized and effective treatment approaches for individuals suffering from both conditions

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