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For example, basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF) promote fibroblast activation, collagen synthesis, and vascularization [3], while antimicrobial peptides (AMPs) contribute to infection control and immune modulation at wound sites [21, 22]

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These results suggest that signaling through MOR may be desensitized through a heterologous mechanism by receptor tyrosine kinase activation and that this mechanism may have important implications for pain control following tissue injury

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The imperative is clear: Neuroprotection in the 21st century must be multimodal, multidisciplinary, and multidimensional