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doi: 10.7717/peerj.6963 363 YukgehnaishK.KumarP.SivachandranP.MarimuthuK.ArshadA.ParayB

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Recently, neural activity mediated by NMDA-receptors (NMDAR) has been coupled with transcriptional activation of glutamate-cysteine ligase, a key enzyme in GSH production, leading to a sustained GSH-based protection against an oxidative insult 26

OPG and RANK/RANKL expression could be upregulated with increased catabolism in AF, NP, or CEP cells exposed to acidic microenvironments or the inflammatory factor IL-1 (63, 64)