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For other parenteral routes such as subcutaneous and intramuscular injections, the bioavailability may still be close to 100 % for most therapeutic drugs (F = 0.751), since little or no significant metabolism of the drug occurs in the skin or muscle and these small molecules (MW 0 min) compared to the intravenous route

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If it is, there could be a functional folate deficiency

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summarized and analyzed all research on the prevalence of CMD in HFpEF patients, finding a high pooled prevalence of 71% [29]