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Patients with high-sensitivity genetic profiles benefit from proactive electrolyte supplementation and structured drinking reminders, while those with lower GLP1R sensitivity may find standard hydration guidelines sufficient

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On the other hand, when women with obesity and lipedema lose more substantial weight through medical or surgical interventions, they can lose some fat from the areas with lipedema, which can then leave them with rolls of excess skin along in the areas of remaining lipedema fat tissue (Figure 4)