They act on different pathways
IGFBP-5 can be either stimulatory or inhibitory depending on context and binds to extracellular matrix, creating localized IGF reservoirs relevant to bone and muscle

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Sterile-filtered aqueous diluent with ~0.9% benzyl alcohol preservative
and (ii) probed the concentration of potassium, an intracellular solute, using a membrane-permeable potassium-sensitive dye, ION Potassium Green (IPG