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[37] [38] The evolution of NiSOD is currently predicted to have occurred around the time of the GOE when a decrease in aquatic bioavailability of Fe took place

~1-week-old male Mmut p.L690Ins/p.L690Ins mice were administered 3.02 10 10 vector genome copies of AAV8.CB7.hMMUT viral rescue vector, as shown before (37), via intraperitoneal injection