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Food decreases the extent of and slightly delays the absorption of metformin, as shown by approximately a 40% lower mean peak plasma concentration (C max ), a 25% lower area under the plasma concentration versus time curve (AUC), and a 35-minute prolongation of time to peak plasma concentration (T max ) following administration of a single 850-mg tablet of metformin with food, compared to the same tablet strength administered fasting

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As a glucagon-like peptide-1 ( GLP-1 ) receptor agonist, it works by mimicking the natural GLP-1 hormone in the body and, in doing so, delays gastric emptying (i.e