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Endocare consistently and significantly decreased pain perception up to 4 hours post-treatment, whereas the control group did not show significant differences

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If a person carries a GIPR variant that affects GIP receptor function, the combined stimulation of both receptors may produce a stronger nausea response than GLP-1 stimulation alone

Accordingly, current European Society of Cardiology (ESC) guidelines [28] for the management of patients with chronic coronary syndrome recommend GLP-1 RA for those with type 2 diabetes mellitus (class I, level A) and the GLP-1 RA semaglutide for those without diabetes mellitus when being overweight (BMI 27kg/m 2 ) or obese (class IIa, level B)