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Well-known gut microbial metabolites are urolithins (derived from ellagitannins), enterolactone and enterodiol (produced from lignans), equol and O -desmethylangolensin (ODMA) (coming from isoflavones catabolism) or -valerolactones (derived from flavan-3-ols) (Reference Toms-Barbern, Selma and Espn110)

Chronical consumption (8 weeks) of a pure arabica dark-roast coffee blend significantly reduced spontaneous DNA strand breaks in blood cells of healthy volunteers, pointing to a DNA protective effect (Pahlke, 2019) and (Schipp 2018)

There is an urgent need for therapies that address multiple aspects of this cardiometabolic syndrome, such as improving blood glucose levels, reducing body weight, and mitigating cardiovascular risk [4,5]

It belongs to a group called nonsteroidal anti-inflammatory drugs (NSAIDs)