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1 If vitamin B 12 deficiency coexists with folate deficiency, vitamin B 12 should be replaced first to prevent subacute combined degeneration of the spinal cord

242,243 In mammalian and zebrafish PD animal models, DJ-1 protects cells from apoptosis by inhibiting p53 transcriptional activity and decreasing Bax protein levels

Secondly, some people are not able to absorb vitamin b12 from the food they consume due to either some health conditions of the digestive system or because of some types of medicines which can reduce the absorption of vitamin b12