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Overall, both classes are indifferently recommended by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) as first-line therapy in patients with T2DM and established ASCVD or multiple ASCVD risk factors to reduce the risk of major adverse cardiovascular events (MACE), such as myocardial infarction, stroke, and cardiovascular death [6, 7]

The Rest of Europe accounts for 30.5% in both 2025 and 2035, driven by growing wellness participation in Nordic and Central European countries and broader access to clean-label antioxidant nutraceuticals