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FIGURE 4 Validation of RNA-seq results and the expression analysis of Wnt/-catenin signaling pathway-related genes To verify the results of RNA-seq, 13 differentially expressed genes, including 6 downregulated and 7 upregulated genes, were randomly selected for qRT-PCR assay

MK-677, technically a growth hormone secretagogue rather than a peptide, offers the convenience of oral administration while stimulating growth hormone release

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This weakens the Notch3-mediated downstream signaling pathway, inducing glioma cell death and indicating that ChaC1 can influence the cytotoxicity of tumor cells induced by temozolomide (69)

Animal studies have shown a potential risk of thyroid C-cell tumours, though the relevance to humans is uncertain