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Circulating mtDAMPs activate polymorphonuclear neutrophils (PMNs) and monocytes through formyl peptide receptor-1 (FPR1), Toll-like receptor 9 (TLR9), and the NLRP3 inflammasome, inducing Ca 2+ flux, mitogen-activated protein (MAP) kinase phosphorylation, neutrophil migration, degranulation, and cytokine release

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