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By blocking NNMT, it shifts intracellular NAD+ and S-adenosylmethionine (SAM) levels, two cofactors tied to energy metabolism, redox balance, and gene regulation in laboratory models

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Elevated NNMT expression often correlates with altered metabolic states

Animal studies using the gold-standard euglycemic clamp technique confirmed that even chronic AOD-9604 treatment produced no adverse effects on insulin sensitivity, despite significant fat loss occurring

Severe allergic reactionssuch as difficulty breathing, rash, or swelling of the face and throatare extremely rare but require immediate medical attention