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Furthermore, selected genera such as Escherichia/Shigella isolated from participants stool samples have been shown to directly trigger a pro-inflammatory state and amyloid- accumulation (Minter et al., 2016)

Similar to the nanosize of protein globules, DNA helix and cell membrane thickness, NPs can easily penetrate through the cell membrane and enter cells and cell organelles (Sukhanova et al., 2018)

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