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All of them were demonstrated to decrease IR at quite high dosages (12, 30, 31), also in PCOS patients undergoing IVF programs (32)

In order to test this concept, male and female C57BL/6 mice, 20 months of age, were given intranasal GHK-Cu, 15 mg/kg daily, for two months

GSH, in turn, acts as a cofactor for GPX4, a specialized enzyme responsible for preventing lipid peroxidation [78]

All this evidence suggests that changes in mitochondrial function in MDD and BD could be key elements in order to better understand the role of the currently used pharmacotherapy and also to develop novel therapies and new treatment strategies, which will be covered in the next section