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B.PodujeC

PMID 8242618

As fat mass increases, more testosterone is diverted to estradiol, and estradiol in turn signals the brain to reduce the hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH) that instruct the testes to produce testosterone and sperm

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In mouse models of insulin resistance, it significantly inhibits NNMT activity in liver and muscle, reduces NAM methylation, increases intracellular NAD+, activates the SIRT1 pathway, promotes phosphorylation of insulin receptor substrate 1 (IRS1), enhances insulin signaling, improves insulin sensitivity, and increases glucose uptake and utilization