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Anecdotally, this felt like a trend

doi: 10.1210/jcem.84.3.5577

5-Amino-1-methylquinolinium (5-Amino-1MQ) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), the cytosolic enzyme that methylates nicotinamide to 1-methylnicotinamide (1-MNA) using S-adenosyl-L-methionine (SAM) as the methyl donor

PMID: 214 KedmiRNajarTAMesaKRGraysonAKroehlingLHaoYet al

With the right medical guidance & nutrition, many of these can be reduced or eliminated

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