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Freeze-thaw cycling can disrupt the copper coordination sphere as well as degrade the peptide backbones, so single-use aliquots are preferable to repeatedly accessing one stock

Zheng P, Schramm RD, Latham KE: Developmental regulation and in vitro culture effects on expression of DNA repair and cell cycle checkpoint control genes in rhesus monkey oocytes and embryos

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10.1016/j.jep.2024.118262 J Ethnopharmacol

The EVOKE and EVOKE Plus trials are examining oral semaglutide in individuals with early Alzheimer's disease, representing some of the largest prospective studies in this area