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More specifically, the amino acids which are replaced appear to be the 2nd, 8th, 15th, and 27th amino acids

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A single-case, proof-of-concept study combined botulinum toxin with anodal tDCS in a cervical dystonia patient, applying the stimulation for 30 min, twice a week, over the right cerebellum (5 sessions), left cerebellum (5 sessions), and right M1+left cerebellum (10 sessions), switching the stimulation site when patient reported no benefit for two consecutive sessions [253]

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Nuance gets lost