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Combining them stacks these effects, which can make common side effects feel much more intense and uncomfortable

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In the case of KATO-III cells, antiproliferative effects were shown at concentrations above 100 g/mL, while in LS174 cells, cytotoxic properties of bromelain were evidenced above 30 g/mL and its cytotoxicity increased with higher bromelain concentrations at 72h (81)

Aug 13 2019;24(16)doi:10.3390/molecules24162930 Kongkam P, Khongkha W, Lopimpisuth C, et al