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PGK-2 is expressed only in spermatozoa

Even with appropriate hormonal replacement, damage to the hypothalamus disrupts integration of peripheral hormonal signals and central neuropeptides, finally resulting in excessive food intake and weight gain [20]

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Its dual GLP-1 and GIP receptor activation produced a 20.9% average body weight reduction at 72 weeks in the SURMOUNT-1 trial, and more recent SURMOUNT-5 head-to-head data confirmed its superiority over Semaglutide

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