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All analyses of the primary and secondary endpoints described above were repeated for the Chinese subpopulation, except for the removal of region as a categorical fixed effect in the model (prespecified)

Cancers most commonly linked to obesity include colorectal, breast (particularly postmenopausal), endometrial, pancreatic, and kidney cancers

The PK analysis set consisted of all participants who received at least one dose of AMG 133 for whom at least one PK parameter or end point could be adequately estimated

Authorship Contributions SJM, JB and TAB contributed with study conception, study design, data interpretation, critical manuscript revision and final manuscript approval

Nonetheless, ePA ensures that, when coverage is allowed, a patients initiation onto therapy is not prevented by paperwork, potentially capturing the drugs value