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Aged mice also have hallmarks of BBB breakdown compared to young mice with increased leakage of IgG into the brain parenchyma, a reduction of the tight junction protein occludin, and a reduction in pericyte coverage and pericyte induced expression of genes in the endothelium [54, 90, 91]

What we actually have in humans This is the crux of the clinician dilemma

Adam L, San Lucas FA, Fowler J, Yu Y, Wu W, Liu Y, Wang H, Menter DG, Tetzlaff MT, Ensor JE, Manyam G, Arold ST, Huff CD, Kopetz S , Scheet P, Overman MJ

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