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Estrogen Amplifies the Drug: Estrogen upregulates GLP-1 receptors and boosts your bodys own GLP-1 production, so menopause directly weakens the drugs effect

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Clin Exp Allergy 46:10331042 Patel D, Sethi N, Patel P et al (2024) Exploring the potential of P-glycoprotein inhibitors in the targeted delivery of anti-cancer drugs: a comprehensive review

They found that the GLP1 receptor variant rs10305420 was associated with slightly more weight loss in those carrying this variant compared with those who lacked it