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HbA1c reduction: Tirzepatide 15mg: -2.30% vs Semaglutide 1mg: -1.86% Additional weight loss vs semaglutide: 5mg: -1.9 kg more, 10mg: -3.6 kg more, 15mg: -5.5 kg more Primary endpoint: All tirzepatide doses were noninferior AND superior to semaglutide Source: Fras et al., NEJM 2021 SURMOUNT-2: Obesity with Type 2 Diabetes 938 adults with obesity AND type 2 diabetes randomized to tirzepatide 10mg, 15mg, or placebo for 72 weeks

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During moderate exercise, you lose 500 to 1,000 mL of fluid per hour through sweat

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