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While principal component analysis (PCA) of the full sample set did not show clear clustering by treatment, three combination-treated tumors formed a distinct subcluster, which was correlated with tumor volume reduction (Supplementary Fig

The study found that the exosomal SP94-Lamp2bRRM, which targets HCC, aids in delivering small interfering RNA to improve sorafenib-induced ferroptosis by inhibiting the expression of GPX4 and DHODH