Likewise, recent comparative studies in sporadic (icv-STZ Mouse) and familial (3xTg-AD mouse) mice models of AD have revealed the transcriptional alteration of more than 80 genes related to synapse function, apoptosis and autophagy, AD-related protein kinases, glucose metabolism, insulin signaling, and mTOR pathway in the hippocampus and the cerebral cortex, not only when compared to WT animals, but also between both AD models (Chen et al., In summary, we hypothesize that by upregulating Gpx4 gene expression and increasing GPx4 protein levels and enzyme activity, DHA initiates a self-protective biochemical strategy in the hippocampal neuron to control non-enzymatic peroxidation of DHA-containing phospholipids in the membrane from cellular and subcellular compartments
A variety of GO enrichment terms were enriched and a subset of representative terms from this cluster were selected and converted into a network layout
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