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The peptide demonstrates multifunctional activity across skin, nervous system, and vascular tissue, with documented gene-regulatory effects that extend beyond simple wound healing [3] [16]

Therefore, improvements in metabolic health may indirectly calm inflammatory skin activity

Participants were randomised (1:1:1:1) using a web-based randomisation system to either once-daily oral semaglutide (3 mg, 7 mg or 14 mg) or once-daily oral sitagliptin 100 mg

Some studies have explored whether these shifts could be linked to improved metabolic markers or changes in gut barrier function

Nausea affected about 47% of participants, and vomiting was reported by about 31%