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These compositional shifts are typically accompanied by decreased short-chain fatty acid synthesis and abnormal bile acid metabolism, which may indirectly mediate MPs toxic effects on distant organsincluding the liver and brainthrough low-grade inflammation and metabolic disturbances [67]

709, 1025 Kortemeier, M

Multivar Behav Res 46(3):399424 Carolino IDR, Molena-Fernandes CA, Tasca RS, Marcon SS, Cuman RK N (2008) Risk factors in patients with type 2 diabetes mellitus

48 Muscle Loss: Significant weight loss can sometimes include loss of muscle mass, which further slows metabolism

In a clinical trial where people with CF were given N-acetylcysteine for 24 weeks and followed for lung function and pulmonary exacerbations, N-acetylcysteine maintained baseline lung function longer than the placebo group but failed to show a significant improvement in exacerbations (Conrad et al., 2015)