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Differences in MACE risk with liraglutide versus placebo between eGFR subgroups in the LEADER CVOT [2] might be coincidental or owing to a specific study population

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Thiazolidinediones: Single-dose pharmacokinetics of rosiglitazone was not meaningfully altered in subjects receiving multiple daily doses of sitagliptin, indicating that sitagliptin is not an inhibitor of CYP2C8-mediated metabolism

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For this reason, oral Wegovy is not recommended for individuals with a personal or family history of medullary thyroid carcinoma or those with multiple endocrine neoplasia syndrome type 2