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Very Low), consistent with the class effect

Its also approved to treat moderate to severe obstructive sleep apnea (OSA) in adults with obesity

This happened when totally inconsistent results were published by several groups using JNK2-deficient mice [36, 134136] and it was later discovered that the reason for the contradictory data was caused by the mislabeling of the background strain for JNK2 KO mice by the vendor [137], which led to the use of WT and KO mice with mismatched genetic background

Clear, sustained suppression: 48 weeks as steady-state levels are reached and the dose steps up

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